Can you overdose on CBD pills? Obviously there are plenty of substances on which you can, but what about CBD in pill form?
After all, you might need to take more than just one at a time, depending on what your pain or anxiety levels are like and it's a natural concern to have. You don't want to take too much of any substance and therefore it's a good idea to be aware of how much you can take.
While it isn't the case that CBD has no risks, it's also the case that there are no known fatalities from CBD overdose. Adverse reactions have been recorded in clinical studies, even including some severe adverse reactions. It is definitely the case that taking too much can be harmful. However, it requires a person to take a rather large amount of CBD over the course of a day.
With that said, the effects of taking too much CBD in a sitting are generally mild.
That sounds kind of complicated, doesn't it? Let's flesh that out.
The question of "can you overdose on CBD pills" is not very specific, is it? A person could mean a number of things when they ask that.
Can you take so much CBD that it becomes lethally toxic?
Yes, but you'd have to work so hard to do it that it basically is never going to happen in the real world.
To flesh that out a bit, the term that the pharmaceutical-medical community uses to express the lethality of a given amount of a substance is LD or "lethal dose," meaning the dosage (in milligrams) of a particular substance kills a certain percentage of test subjects that take it.
The most common measurement is LD50, meaning the specific amount of the substance killed 50 percent of test subjects that took it.
So, the LD50 of CBD for humans is not known. However, a smattering of animal studies have produced a figure of somewhere between 200 mg per kg of body weight and 250 mg per kg of body weight, depending on the species.
To put that in perspective, a person who weighs 100 kg (that's about 220 lbs) would have to take 1,000 25mg CBD capsules to absorb 250 mg/kg. (That's 25mg times 10 for 250mg of CBD, times 100 for 250 mg per kg of bodyweight.) You have to be pretty determined to swallow 1,000 pills.
You'd also have to be rich. Let's say a bottle of 25mg CBD capsules retails for $84.99 and contains 30 softgels. You'd have to buy 34 bottles, which adds up to $2,890 before tax and shipping.
So can you die from CBD poisoning? In theory, yes, but - again - there aren't any real-world circumstances in which it's likely that a person ever will.
Are there any side effects to CBD pills, in case you take one or two more than you normally would?
Yes, but they are generally very mild. You can have a look at this literature review that appeared in Current Neuropharmacology at the National Institutes of Health that covers the topic in-depth if you'd like to read up for yourself.
A handful of studies have addressed the topic of adverse reactions to CBD, whether as CBD pills, oil or if CBD is given intravenously, and the most common side effects are diarrhea, lethargy and fatigue.
So most likely, the worst you'll have to worry about is feeling sleepy and/or having the runs. Granted, it's not that those things are good but as far as adverse drug reactions go, those are pretty mild.
With that said, there have been some other reactions that occur in some patients. Use of CBD has coincided with cardiac events in some animal studies and also in humans, though human subjects only experienced cardiac events if they were already suffering from a heart condition to begin with. Other common side effects included elevated liver enzymes and fever.
A few studies noted an increase in seizures, but it should be noted that those studies were testing the effects of CBD on epileptic patients, meaning that people had seizures...who were already having seizures.
However, one trend among those patients who suffered side effects in multiple studies and trials was ingesting 20 mg/kg of bodyweight, which would require a 100 kg person to take 8 25mg CBD pills or 20 pills of 10mg each.
So yes, there are side effects of CBD usage, and if you take a lot of it you CAN suffer some adverse reactions. However, you have to take a lot more of it than anybody normally does.
but you can opt out at any time.